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Related Concept Videos

Mass Analyzers: Common Types01:19

Mass Analyzers: Common Types

The quadrupole mass analyzer consists of four cylindrical metal rods arranged in a diamond carrying a DC voltage and a radio-frequency AC voltage. The motion of ions through the quadrupole depends on the field strength, causing only ions of a certain m/z to resonate successfully and strike the detector at a given field strength. Though the transmission rate for these analyzers is high, the exact elemental composition of the sample is not determined because of low resolution; however, they are...
Electrospray Ionization (ESI) Mass Spectrometry01:12

Electrospray Ionization (ESI) Mass Spectrometry

Higher molecular weight biomolecules are nonvolatile compounds that may decompose before ionizing or vaporizing during mass analysis with conventional electron impact ionization methods. Accordingly, electrospray ionization (ESI) is the favored method for vaporizing and ionizing biomolecules as it circumvents rapid fragmentation and enables the recording of mass signals for the entire biomolecule.
ESI utilizes electrical energy to transfer ions from the liquid phase of the sample into the...
Mass Spectrometers01:16

Mass Spectrometers

This lesson details the instrumentation of a mass spectrometer—a physical instrument to perform mass spectrometry on analyte molecules and record the characteristic mass spectra. This is achieved via three chief functions:
Mass Analyzers: Overview01:13

Mass Analyzers: Overview

The mass analyzer is a crucial component of the mass spectrometer. In the ionization chamber, the vaporized sample is bombarded with a high-energy electron beam to generate a radical cation and further fragment into neutral molecules, radicals, and cations. A series of negatively charged accelerator plates accelerate the cations into the mass analyzer. The mass analyzer separates ions according to their mass-to-charge (m/z) ratios and then directs them to the detector. The common types of mass...
Mass Spectrum: Interpretation01:24

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An unknown compound can be established by identifying the molecular ion peak in the mass spectrum. The molecular ion peak is often weak or absent due to the predominance of fragmentation in high-energy electron beams. In such cases, a soft-energy electron beam can be used to scan the spectrum to enhance the intensity of the molecular ion peak. Additionally, chemical ionization, field ionization, and desorption ionization spectra are used to obtain a relatively intense molecular ion peak.To...
Mass Spectrometry: Overview01:19

Mass Spectrometry: Overview

Mass spectrometry is an analytical technique used to determine the molecular mass and molecular formula of a compound. The basic principle of mass spectrometry is to generate ions from the analyte molecule and measure these ion abundances against their molecular mass. One common type of ionization, known as electron ionization or EI, bombards the analyte molecules in the gas phase with high-energy electron beams. The electron beams displace an electron from the molecule and leave behind a...

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T-wave Ion Mobility-mass Spectrometry: Basic Experimental Procedures for Protein Complex Analysis
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Published on: July 31, 2010

An electrostatic autoresonant ion trap mass spectrometer.

A V Ermakov1, B J Hinch

  • 1Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854, USA.

The Review of Scientific Instruments
|February 2, 2010
PubMed
Summary
This summary is machine-generated.

A new method for ion extraction from anharmonic electrostatic traps enables autoresonant ion extraction (ART-MS). This cost-effective technique offers high mass resolution without complex components, paving the way for miniaturized mass spectrometers.

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Area of Science:

  • Physics
  • Analytical Chemistry
  • Instrument Design

Background:

  • Electrostatic traps are crucial for ion confinement.
  • Anharmonicity in traps is essential for autoresonant ion extraction.
  • Existing mass spectrometers often rely on complex and expensive components.

Purpose of the Study:

  • Introduce a novel method for ion extraction from anharmonic electrostatic traps.
  • Design and demonstrate new autoresonant trap mass spectrometers (ART-MS).
  • Evaluate the performance and dependencies of the developed ART-MS prototypes.

Main Methods:

  • Utilized ion trajectory simulations for designing novel ART-MS.
  • Developed ART-MS based on principles of anharmonicity and autoresonance.
  • Tested prototypes to determine mass resolution, pressure dependencies, and RF field strength dependencies.

Main Results:

  • Demonstrated a mass resolution of approximately 60 for ART-MS prototypes.
  • Reported on the sensitivity dependencies on pressure and RF field strength.
  • Confirmed that the new MS designs avoid magnets, complex electronics, and buffer gases.

Conclusions:

  • The novel ART-MS designs are inexpensive, simple, and easily miniaturized.
  • The developed method provides a cost-effective alternative for mass spectrometry.
  • Potential applications for these compact and affordable mass spectrometers are discussed.