Related Experiment Video
Updated: Jun 16, 2026

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
Published on: December 27, 2013
Development of a new delivery system consisting in 'drug-in cyclodextrin-in PLGA nanoparticles'
Paola Mura1, Francesca Maestrelli, Matteo Cecchi
1University of Florence, Faculty of Pharmacy, Department of Pharmaceutical Sciences, Florence, Italy. paola.mura@unifi.it
Abstract:
A combined approach based on drug cyclodextrin (CD) complexation and loading into PLGA nanoparticles (NP) has been developed to improve oxaprozin therapeutic efficiency. This strategy exploits the solubilizing and stabilizing properties of CDs and the prolonged-release and targeting properties of PLGA NPs. Drug-loaded NPs, prepared by double-emulsion, were examined for dimensions, zeta-potential and entrapment efficiency. Solid-state studies demonstrated the absence of drug-polymer interactions and assessed the amorphous state of the drug-CD complex loaded into NPs. Drug release rate from NPs was strongly influenced by the presence and kind of CD used. The percentage released at 24 h varied from 16% (plain drug-loaded NPs) to 50% (drug-betaCD-loaded NPs) up to 100% (drug-methylbetaCD-loaded NPs). This result suggests the possibility of using CD complexation not only to promote, but also to regulate drug release rate from NPs, by selecting the proper type of CD or CD combination.
Related Concept Videos
Site-Targeted Drug Delivery Systems: Polymeric Carriers
Oral Drug Delivery Systems: Continuous-Release Systems
Oral Drug Delivery Systems: Delayed-Release Systems
Modified-Release Drug Delivery Systems: Rate-Programmed II
Oral Drug Delivery Systems: Introduction
Modified-Release Drug Delivery Systems: Rate-Programmed I

