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Transcutaneous Assessment of Renal Function in Conscious Rodents
Published on: March 26, 2016
Screening for decreased renal function in taxi drivers in Tehran, Iran
Mitra Mahdavi-Mazdeh1, Seyed Saeed Hashemi Nazri, Ebrahim Hajghasemi
1Department of Nephrology, Tehran University of Medical Sciences; Research Center of Iranian Tissue Bank, Tehran, Iran.
Renal Failure
|February 2, 2010
Summary
Screening taxi drivers for chronic kidney disease (CKD) revealed a 6.5% prevalence of reduced estimated glomerular filtration rate (eGFR). Early detection and intervention are crucial for preventing end-stage renal disease (ESRD).
Area of Science:
- Nephrology
- Public Health
- Epidemiology
Background:
- Rising end-stage renal disease (ESRD) prevalence and treatment costs necessitate preventive strategies, particularly in developing nations.
- Early screening and treatment can slow CKD progression, reduce healthcare burdens, and save lives.
Purpose of the Study:
- To assess the prevalence of chronic kidney disease (CKD) among taxi drivers in Tehran.
- To identify risk factors associated with reduced estimated glomerular filtration rate (eGFR) in this population.
Main Methods:
- A large-scale, population-based cross-sectional survey was conducted in Tehran in 2007.
- Included 31,999 taxi drivers and applicants, collecting demographic data, blood pressure, medical history, and laboratory tests (creatinine, lipid profile, CBC, fasting blood sugar, urinalysis).
- eGFR was calculated using the MDRD equation.
Main Results:
- Overall prevalence of eGFR <60 mL/min/1.73 m(2) was 6.5% (higher in females: 13.7% vs. 6.4% in males).
- Proteinuria prevalence was higher in females (1.8%) compared to males (0.6%) in the normal GFR group.
- Age, LDL cholesterol, hypertension, blood glucose, and BMI were significant risk factors for low eGFR.
Conclusions:
- CKD prevalence is notably higher in older individuals, females, hypertensives, and uncontrolled diabetics.
- Identifying CKD patients and implementing preventive measures are essential to reduce ESRD incidence.
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