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Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma happens...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...

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Related Experiment Video

Updated: Jun 16, 2026

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes
11:47

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes

Published on: March 4, 2022

Chronic progressive nephropathy: functional, morphological, and morphometrical studies.

Mariana C Fiori1, Georgina P Ossani, Néstor R Lago

  • 1CESyMA. Escuela de Ciencia y Tecnología, Universidad Nacional de General San Martín, General Paz 5445 (1650), San Martín, Argentina.

Renal Failure
|February 2, 2010
PubMed
Summary
This summary is machine-generated.

Chronic progressive nephropathy in aged rats involves glomerulosclerosis and tubule atrophy. Glomerular changes, not vascular alterations, are key to disease progression.

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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
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Last Updated: Jun 16, 2026

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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

Area of Science:

  • Nephrology
  • Pathology
  • Gerontology

Background:

  • Chronic progressive nephropathy (CPN) is a significant kidney disease.
  • Understanding CPN pathogenesis is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate the functional, morphological, and morphometrical characteristics of CPN in aged rats.
  • To elucidate the role of vascular and glomerular changes in CPN progression.

Main Methods:

  • Studied aged male rats (18-26 months) with CPN and young controls (3 months).
  • Utilized light microscopy, high-resolution light microscopy, and electron microscopy for morphological analysis.
  • Conducted glomerular and vascular morphometrical studies.

Main Results:

  • CPN rats exhibited proteinuria, slightly elevated serum creatinine, and normal blood pressure.
  • Morphological findings included glomerulosclerosis, tubule atrophy, interstitial fibrosis, and vascular hyalinosis.
  • Glomerular studies revealed a biphasic pattern towards obsolescence; vascular studies showed increased media thickness.

Conclusions:

  • Glomerular sequential changes are of paramount significance in CPN progression.
  • Vascular system changes appear less critical in the pathogenesis of CPN.