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Updated: Jun 16, 2026
08:50
5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
Acute renal failure under dasatinib therapy.
Sultan Ozkurt1, Gokhan Temiz, Mustafa Fuat Acikalin
1Department of Nephrology, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey.
Renal Failure
|February 2, 2010
Summary
Dasatinib effectively treats chronic myeloid leukemia but can cause acute renal failure. Promptly interrupting dasatinib therapy is crucial for patient recovery.
Area of Science:
- Oncology
- Pharmacology
- Nephrology
Background:
- Dasatinib is a potent tyrosine kinase inhibitor for imatinib-resistant chronic myeloid leukemia.
- Its effects on renal function are not well-documented.
- Limited data suggests a potential link between dasatinib and renal complications.
Observation:
- A patient with imatinib-resistant chronic myeloid leukemia developed gastroenteritis and acute renal failure shortly after starting dasatinib.
- These adverse events resolved completely upon discontinuation of dasatinib therapy.
- This case highlights a potential adverse effect of dasatinib on kidney function.
Findings:
- Dasatinib, while effective against BCR-ABL, may pose a risk for acute renal failure.
- Gastroenteritis was observed concurrently with renal impairment in this patient.
- Renal function recovery was rapid after dasatinib withdrawal.
Implications:
- Close clinical monitoring of renal function is essential for patients receiving dasatinib.
- Timely interruption of dasatinib therapy may prevent severe renal complications.
- Further research is needed to elucidate the mechanisms of dasatinib-induced nephrotoxicity.
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