Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Gut-Brain Axis

Gut-Brain Axis

The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...

Physiology of Enteric Nervous System and Gut Health

Physiology of Enteric Nervous System and Gut Health

The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...

Neural Regulation

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

Nerve Supply of the GI Tract

Nerve Supply of the GI Tract

The neuronal supply to the gastrointestinal (GI) tract is essential for regulating various functions, including digestion, absorption, and movement of food. This intricate network of nerves is known as the enteric nervous system (ENS), often referred to as the "second brain" of the body.
The enteric nervous system consists of two major plexuses: the myenteric plexus (Auerbach's plexus) and the submucosal plexus (Meissner's plexus). These plexuses are located within the layers of the GI tract...

Anatomy of the Intestines

Anatomy of the Intestines

Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the small...

The Skin Microbiota

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Real-World Evaluation of AI-Assisted Readout of Skin Prick Automated Test Results.

Allergy·2026

Same author

Transforming orthotopic liver transplantation: Innovative dry-lab simulation model in mice.

Current problems in surgery·2025

Same author

Identifying Key Questions and Challenges in Microchimerism Biology.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025

Same author

Psychometric properties of the Maternal Postnatal Attachment Scale and the Postpartum Bonding Questionnaire in three German samples.

BMC pregnancy and childbirth·2024

Same author

Delayed Induction of Noninflammatory SARS-CoV-2 Spike-Specific IgG4 Antibodies Detected 1 Year After BNT162b2 Vaccination in Children.

The Pediatric infectious disease journal·2024

Same author

Fetal lung growth predicts the risk for early-life respiratory infections and childhood asthma.

World journal of pediatrics : WJP·2024

Search research articles

Related Experiment Video

Updated: Jun 16, 2026

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis

Published on: July 28, 2023

Is there a 'gut-brain-skin axis'?

Petra Arck¹, Bori Handjiski, Evelin Hagen

¹Center of Internal Medicine and Dermatology, Charité University Medicine Berlin, Berlin, Germany. petra.arck@charite.de

Experimental Dermatology

|February 2, 2010

Summary

This summary is machine-generated.

Probiotics can reduce stress-induced skin inflammation and hair growth inhibition by modulating the gut-brain-skin axis. This research introduces a new model for how gut bacteria impact skin homeostasis and stress responses.

More Related Videos

Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation

Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation

Published on: December 29, 2023

Related Experiment Videos

Last Updated: Jun 16, 2026

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis

Published on: July 28, 2023

Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation

Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation

Published on: December 29, 2023

Area of Science:

Neuroimmunology
Microbiome research
Dermatology

Background:

Emerging evidence highlights inter-organ communication axes, including the brain-gut and brain-skin axes.
The brain-skin axis mediates neurogenic skin inflammation and hair growth inhibition under stress.
The gut microbiome's role in systemic health and its interaction with the brain and skin is increasingly recognized.

Purpose of the Study:

To investigate the effect of a specific Lactobacillus strain on stress-induced neurogenic skin inflammation and hair growth inhibition in mice.
To propose a unifying model of the gut-brain-skin axis.
To explore the potential of probiotics in modulating skin homeostasis and stress responses.

Main Methods:

Administration of a Lactobacillus strain to mice.
Induction of stress to elicit neurogenic skin inflammation and hair growth inhibition.
Observation and analysis of skin and hair follicle responses.

Main Results:

Ingestion of the Lactobacillus strain significantly dampened stress-induced neurogenic skin inflammation.
The Lactobacillus strain also inhibited stress-induced hair growth suppression.
Pilot observations suggest a beneficial effect on hair follicle cycling.

Conclusions:

A novel gut-brain-skin axis model is proposed, integrating previous concepts.
Probiotic modulation of the gut microbiome can mitigate stress-induced skin inflammation.
Probiotics show potential for positively influencing skin homeostasis, inflammation, hair growth, and stress responses.