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Urinary N-telopeptides of type I collagen in healthy children

Jun Sato1, Kosei Hasegawa, Hiroyuki Tanaka

  • 1Department of Pediatrics, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan. nemunemu@mx81.tiki.ne.jp

Pediatrics International : Official Journal of the Japan Pediatric Society
|February 2, 2010
PubMed

Insights

Urinary N-telopeptides of type I collagen (NTx) levels are higher in children than adults. The first voided urine specimen may serve as a reliable marker for bone resorption in pediatric populations.

Area of Science:

  • Pediatric Endocrinology
  • Bone Metabolism
  • Biomarkers

Background:

  • Urinary N-telopeptides of type I collagen (NTx) are specific markers of bone resorption.
  • Previous reports suggest higher NTx levels in children compared to adults, but data is limited.
  • Understanding pediatric NTx levels is crucial for assessing bone health.

Purpose of the Study:

  • To establish reference values for urinary NTx in healthy children.
  • To investigate the age-related changes in urinary NTx excretion in children.
  • To examine the circadian rhythm of urinary NTx excretion between first and second voided urines.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) was used to measure urinary NTx.
  • 362 healthy Japanese children (6-11 years) were assessed for age-related changes.
  • 30 children (6-12 years) provided first and second voided urine samples to evaluate circadian variation.

Main Results:

  • Urinary NTx levels were significantly higher in children than in healthy adults.
  • NTx levels generally decreased with age in boys and in girls aged 6-9 years.
  • NTx levels in the first voided urine were significantly higher than in the second, indicating circadian variation.

Conclusions:

  • Pediatric urinary NTx levels exceed those of adults, confirming higher bone resorption rates in children.
  • The first voided urine NTx measurement shows promise as a valuable biomarker for bone resorption in children.
  • Circadian rhythm influences NTx excretion, with higher levels observed in the morning first void.
Abstract

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