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[Changes of exhaled nitric oxide and peripheral blood eosinophils in children with asthma]

Chun-Long Ge1, Chuang-Li Hao, Ning-Bo Tang

  • 1Department of Allergy, Yantai Yuhuangding Hospital, Yantai, Shangdong 264000, China.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|February 2, 2010
PubMed

Insights

Exhaled nitric oxide (eNO) and peripheral blood eosinophils (EOS) are elevated in children with asthma, allergic rhinitis, and cough variant asthma. These markers, particularly eNO, can indicate eosinophilic airway inflammation in pediatric asthma.

Area of Science:

  • Pediatric Pulmonology
  • Allergy and Immunology
  • Biomarker Research

Context:

  • Asthma is a common chronic respiratory disease in children, often associated with airway inflammation.
  • Allergic rhinitis and cough variant asthma are specific phenotypes that may present with distinct inflammatory profiles.
  • Accurate assessment of airway inflammation is crucial for diagnosis and management.

Purpose:

  • To investigate exhaled nitric oxide (eNO) and peripheral blood eosinophils (EOS) in children with asthma, asthma with allergic rhinitis (AS/AR), and cough variant asthma (CVA).
  • To determine the correlation between eNO and EOS levels in these pediatric respiratory conditions.
  • To evaluate the diagnostic value of eNO detection in children with asthma.

Summary:

  • Children with AS, AS/AR, and CVA exhibited significantly higher eNO and EOS levels compared to controls.
  • The AS/AR group showed the highest levels of both eNO and EOS.
  • eNO levels positively correlated with EOS levels in the asthma group, suggesting a link to eosinophilic inflammation.

Impact:

  • Exhaled nitric oxide (eNO) serves as a non-invasive marker reflecting eosinophilic airway inflammation in pediatric asthma.
  • Findings support the use of eNO measurements in the clinical evaluation of children with atopic respiratory symptoms.
  • This research aids in understanding the inflammatory pathways in different asthma phenotypes in children.
Abstract

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