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Related Concept Videos

Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma-IV: Nursing Management01:30

Asthma-IV: Nursing Management

The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...

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Related Experiment Video

Updated: Jun 16, 2026

Real-time Imaging of Leukotriene B4 Mediated Cell Migration and BLT1 Interactions with &beta;-arrestin
13:45

Real-time Imaging of Leukotriene B4 Mediated Cell Migration and BLT1 Interactions with β-arrestin

Published on: December 23, 2010

[Urinary leukotrience E(4) level in children with asthma].

Mei-Juan He1, Qiang Chen, Jian-Mei Liu

  • 1Department of Respiratory Medicine, Jiangxi Children's Hospital, Nanchang 330006, China.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|February 2, 2010
PubMed
Summary

Urinary leukotriene E(4) (LTE(4)) levels are elevated in children with asthma. Measuring urinary LTE(4) can aid in asthma diagnosis and predict treatment response to leukotriene receptor antagonists.

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Last Updated: Jun 16, 2026

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Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

Area of Science:

  • Biochemistry
  • Immunology
  • Pediatrics

Context:

  • Cysteinyl leukotrienes (CysLTs) are key mediators in asthma pathogenesis, contributing to airway inflammation and remodeling.
  • Urinary leukotriene E(4) (LTE(4)) offers a noninvasive method to assess systemic CysLT activity.

Purpose:

  • To investigate the clinical significance of urinary LTE(4) levels in childhood asthma.
  • To evaluate urinary LTE(4) as a diagnostic and prognostic marker in pediatric asthma patients.

Summary:

  • This study compared urinary LTE(4) levels in 60 children with acute asthma and 20 healthy controls, assessing levels during acute and convalescent phases.
  • Asthmatic children showed significantly higher urinary LTE(4) levels than controls. Levels decreased during convalescence, with montelukast treatment yielding greater reductions than conventional therapy.
  • No correlation was found between urinary LTE4 and airway resistance (Rint) during the acute phase.

Impact:

  • Urinary LTE(4) is a valuable biomarker for diagnosing asthma in children.
  • Elevated urinary LTE(4) can predict asthma control and indicate susceptibility to leukotriene receptor antagonist therapy.