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Updated: Jun 16, 2026
Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
Treatment outcome of mineral trioxide aggregate: repair of root perforations
Johannes Mente1, Nathalie Hage, Thorsten Pfefferle
1Department of Conservative Dentistry, Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany. johannes.mente@med.uni-heidelberg.de
Introduction:
The use of biocompatible materials like mineral trioxide aggregate (MTA) may improve the prognosis of teeth with root perforations.
Methods:
The treatment outcome of root perforations repaired between 2000 and 2006 with MTA was investigated. Twenty-six patients received treatment with MTA in 26 teeth with root perforations. Treatment was performed by supervised undergraduate students (29%), general dentists (52%), or dentists who had focused on endodontics (19%). Perforation repair by all treatment providers was performed using a dental operating microscope. Calibrated examiners assessed clinical and radiographic outcome 12 to 65 months after treatment (median 33 months, 81% recall rate). Pre-, intra-, and postoperative information relating to potential prognostic factors was evaluated.
Results:
Of 21 teeth examined, 18 teeth (86%) were classified as healed. None of the analyzed potential prognostic factors had a significant effect on the outcome.
Conclusions:
MTA appears to provide a biocompatible and long-term effective seal for root perforations in all parts of the root.