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Published on: February 10, 2023
Venous thromboembolism in children
Neil A Goldenberg1, Timothy J Bernard
1Mountain States Regional Hemophilia and Thrombosis Center, Aurora, CO 80045-0507, USA.
Insights
Pediatric venous thromboembolism (VTE) is a growing concern due to increased survival rates and invasive procedures. This review covers VTE causes, diagnosis, and management in children.
Area of Science:
- Pediatric Medicine
- Hematology
- Vascular Medicine
Background:
- Improved survival in critically ill children increases risk for venous thromboembolism (VTE).
- Increased use of invasive vascular devices contributes to pediatric VTE.
- Vascular events are increasingly recognized in the pediatric population.
Purpose of the Study:
- To provide a comprehensive overview of pediatric venous thromboembolism (VTE).
- To discuss the etiology, epidemiology, clinical presentation, diagnosis, and management of pediatric VTE.
- To highlight prognostic indicators, long-term outcomes, and areas for future research in pediatric VTE.
Main Methods:
- Literature review focusing on etiology, epidemiology, and clinical aspects of pediatric VTE.
- In-depth discussion of diagnostic evaluation and management strategies.
- Consideration of prognostic factors and long-term outcomes based on existing evidence.
Main Results:
- Venous thromboembolism (VTE) is a significant and increasing concern in pediatrics.
- Understanding the background, clinical characterization, and diagnostic approaches is crucial for managing pediatric VTE.
- Evidence-based management and further research are needed for optimal long-term outcomes.
Conclusions:
- Pediatric venous thromboembolism (VTE) requires careful consideration due to rising incidence.
- Effective management involves thorough clinical characterization and diagnostic evaluation.
- Further research is essential to improve prognostic indicators and long-term outcomes for pediatric VTE.
Abstract:
With improved pediatric survival from serious underlying illnesses, greater use of invasive vascular procedures and devices, and a growing awareness that vascular events occur among the young, venous thromboembolism (VTE) increasingly is recognized as a critical pediatric concern. This review provides background on etiology and epidemiology in this disorder, followed by an indepth discussion of approaches to the clinical characterization, diagnostic evaluation, and management of pediatric VTE. Prognostic indicators and long-term outcomes are considered, with emphasis on available evidence underlying current knowledge and key questions for further investigation.
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