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Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Published on: August 4, 2021

Development of guideline-based quality indicators for recurrent miscarriage.

E van den Boogaard¹, M Goddijn, N J Leschot

¹Centre for Reproductive Medicine, Department of Obstetrics and Gynaecology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands. e.vandenboogaard@amc.uva.nl

Reproductive Biomedicine Online

|February 2, 2010

Summary

This study developed 23 quality indicators for recurrent miscarriage (RM) care. All consensus-based recommendations were accepted, highlighting their importance for gynecologists in clinical practice.

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Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Published on: August 4, 2021

Platform for Quantitative Detection of Endometrial Immune Cells Based on Immunohistochemistry and Digital Image Analysis

Platform for Quantitative Detection of Endometrial Immune Cells Based on Immunohistochemistry and Digital Image Analysis

Published on: October 13, 2023

Area of Science:

Reproductive Medicine
Clinical Quality Improvement

Background:

Recurrent miscarriage (RM) is a complex clinical issue.
Evidence-based guidelines exist, but adherence monitoring is needed.
Quality indicators are essential for assessing care in RM patients.

Purpose of the Study:

To develop valid quality indicators for recurrent miscarriage (RM) care.
To assess the relationship between guideline evidence level and indicator acceptance.

Main Methods:

Utilized the RAND-modified Delphi method with 11 gynecologist experts.
Appraised recommendations from the Dutch guideline on RM.
Selected 23 key recommendations covering diagnostics, lifestyle, therapy, and counseling.

Main Results:

A set of 23 quality indicators for RM care was generated.
All Level A (high) and Level D (consensus) recommendations were accepted as indicators.
Acceptance rates were 64% for Level B and 22% for Level C recommendations.

Conclusions:

The study successfully created 23 quality indicators for recurrent miscarriage (RM) management.
The acceptance of all consensus-based recommendations underscores their clinical significance.
These indicators can help measure and improve the quality of care for couples experiencing RM.