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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
What is Genetic Engineering?00:49

What is Genetic Engineering?

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Updated: Jun 16, 2026

Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration
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Genetically modified cells in regenerative medicine and tissue engineering.

Dima Sheyn1, Olga Mizrahi, Shimon Benjamin

  • 1Hebrew University of Jerusalem, Israel.

Advanced Drug Delivery Reviews
|February 2, 2010
PubMed
Summary

Regenerative medicine uses gene and cell therapy to restore tissues. This review covers advances and challenges in bringing these therapies from the lab to patients.

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Area of Science:

  • Regenerative Medicine
  • Gene Therapy
  • Cell Therapy
  • Tissue Engineering

Background:

  • Regenerative medicine aims to restore damaged or aging cells and tissues.
  • Advances in gene transfer, imaging, and cell biology have propelled the field.
  • Genetically engineered cells are key tools, but their development faces challenges.

Purpose of the Study:

  • To review recent progress in gene and cell therapy for regenerative medicine.
  • To identify and discuss key hurdles in clinical translation.
  • To provide an overview of the path from laboratory research to clinical practice.

Main Methods:

  • Literature review of recent advances in gene and cell therapy.
  • Analysis of challenges and bottlenecks in clinical translation.
  • Discussion of prospective clinical applications and practice.

Main Results:

  • Significant technological progress has been made in gene transfer and imaging.
  • Increased understanding of cell biology has opened new avenues.
  • Several impediments hinder the clinical application of gene and cell therapies.

Conclusions:

  • Gene and cell therapy hold promise for treating severe medical conditions.
  • Overcoming laboratory-to-clinic translation challenges is crucial.
  • Further research and development are needed for successful clinical implementation.