[Is Cerebellar Soluble Lectin a major immunological target in multiple sclerosis?]

In a recent paper: (Zanetta J.P. et al., Lancet, 1990, 335, 1482-1484) the authors showed that antibodies against the mannose-binding protein Cerebellar Soluble Lectin (CSL) are present in the cerebrospinal fluid of most multiple sclerosis patients. Herein, the properties and roles of the molecule as they are currently understood are described; hypotheses suggested by the consistent presence of anti-CSL antibodies in multiple sclerosis patients are discussed.