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Related Experiment Video

Updated: Jun 16, 2026

Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis
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Strontium ranelate improves implant osseointegration.

Laurent Maïmoun1, Tara C Brennan, Isabelle Badoud

  • 1Division of Bone Diseases [WHO Collaborating Center for Osteoporosis Prevention], Department of Rehabilitation and Geriatrics and Faculty of Medicine, University Hospital of Geneva, Geneva 14, Switzerland. laurent.maimoun@laposte.net

Bone
|February 2, 2010
PubMed
Summary

Strontium ranelate (SrRan) significantly enhanced implant fixation and osseointegration in rats. This antiosteoporotic agent improved bone microarchitecture and material properties, suggesting potential benefits for orthopedic and dental surgery.

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Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Dental Implantology
  • Bone Biology

Background:

  • Endosseous implants are crucial in orthopedics and dentistry, especially for aging populations.
  • Implant failure is common in patients with poor bone quality, negatively impacting osseointegration.
  • Strontium ranelate (SrRan) is an agent that influences bone turnover and biomaterial properties.

Purpose of the Study:

  • To investigate the efficacy of strontium ranelate (SrRan) in improving osseointegration of titanium implants.
  • To assess the impact of SrRan on bone microarchitecture, biomaterial properties, and mechanical fixation.

Main Methods:

  • Titanium implants were placed in rat tibias.
  • Animals received oral strontium ranelate (SrRan) or saline for 8 weeks.

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Last Updated: Jun 16, 2026

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  • Pull-out strength, microCT, nanoindentation, and bone-to-implant contact were evaluated.

    • Main Results:

    • SrRan significantly increased implant pull-out strength by 34%.
    • Bone microarchitecture improved, with increased bone volume/tissue volume (BV/TV), trabecular thickness (Tb.Th), and decreased connectivity density (Conn.D).
    • Bone-to-implant contact increased by 19%, and bone material properties (modulus, hardness) were enhanced.

    Conclusions:

    • SrRan, an antiosteoporotic agent, enhances mechanical implant fixation.
    • Improved osseointegration is linked to SrRan's positive effects on bone microarchitecture and biomaterial properties.
    • Results suggest SrRan may benefit orthopedic and dental surgery by improving implant osseointegration.