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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...

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Related Experiment Video

Updated: Jun 16, 2026

Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve
09:13

Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve

Published on: June 14, 2017

How has proteomics informed transfusion biology so far?

Giancarlo Liumbruno1, Angelo D'Alessandro, Giuliano Grazzini

  • 1Italian National Blood Centre, Istituto Superiore di Sanità, Rome, Italy.

Critical Reviews in Oncology/Hematology
|February 2, 2010
PubMed
Summary

Proteomics offers new ways to ensure blood product quality and discover biomarkers for component integrity and stem cell function. This technology promises to advance transfusion medicine from the lab to clinical practice.

Related Experiment Videos

Last Updated: Jun 16, 2026

Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve
09:13

Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve

Published on: June 14, 2017

Area of Science:

  • Transfusion Medicine
  • Proteomics
  • Biomarker Discovery

Background:

  • The genomic era has limitations; proteomics is emerging as a key field.
  • Proteomics can enhance blood component quality and safety.
  • Current applications are limited, but potential is high.

Purpose of the Study:

  • To explore the role of proteomics in transfusion medicine.
  • To identify potential applications of proteomics in blood banking.
  • To highlight the discovery of novel biomarkers.

Main Methods:

  • Proteomic investigations of blood components.
  • Analysis of protein fractions during processing and storage.
  • Biomarker discovery for blood component integrity and stem cell function.

Main Results:

  • Proteomics can assess blood component quality before and during storage.
  • It can verify the impact of production and pathogen reduction processes.
  • Potential for discovering biomarkers for blood component integrity and stem cell function.

Conclusions:

  • Proteomics holds significant promise for improving blood product quality and clinical applications.
  • Further research may lead to routine clinical use of proteomics in transfusion medicine.
  • The integration of proteomic expertise into clinical practice is anticipated.