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Multimodal Study of Murine Cardiovascular Remodeling: Four-Dimensional Ultrasound and Mass Spectrometry Imaging
Published on: January 10, 2025
Left ventricular mass and ventricular remodeling among Hispanic subgroups compared with non-Hispanic blacks and
Carlos J Rodriguez1, Ana V Diez-Roux, Andrew Moran
1Department of Medicine, Mailman School of Public Health, Columbia University, New York, New York, USA.
Insights
Hispanic subgroups, particularly those of Caribbean and Mexican origin, show a higher prevalence of left ventricular hypertrophy (LVH) and abnormal left ventricular (LV) remodeling compared to non-Hispanic whites, highlighting ethnic variations in cardiovascular risk.
Area of Science:
- Cardiology
- Population Health
- Medical Imaging
Background:
- Hispanics represent the largest and fastest-growing ethnic minority in the U.S.
- Limited data exists on left ventricular hypertrophy (LVH) and left ventricular (LV) geometry across diverse Hispanic subgroups.
- Understanding these variations is crucial for accurate cardiovascular risk assessment.
Purpose of the Study:
- To investigate the prevalence of LVH and LV remodeling patterns in different Hispanic subgroups.
- To compare these patterns with those observed in non-Hispanic whites.
- To identify potential disparities in cardiovascular health within the Hispanic population.
Main Methods:
- Utilized cardiac magnetic resonance imaging (CMR) in 4,309 participants aged 45-84 from the Multi-Ethnic Study of Atherosclerosis (MESA).
- Categorized Hispanic participants into subgroups based on self-reported ancestry (Mexican, Caribbean, Central/South American).
- Defined LVH based on indexed LV mass and LV remodeling by LVH presence and LV mass to LV end-diastolic volume ratio.
Main Results:
- Hispanic subgroups exhibited a higher likelihood of LVH compared to non-Hispanic whites after adjusting for covariates.
- Caribbean-origin Hispanics (OR: 1.8) and Mexican-origin Hispanics (OR: 2.2) showed significantly higher odds of LVH.
- All Hispanic subgroups displayed a greater prevalence of both concentric and eccentric hypertrophy than non-Hispanic whites (p < 0.001).
Conclusions:
- Caribbean-origin Hispanics demonstrated a higher prevalence of LVH and abnormal LV remodeling compared to non-Hispanic whites.
- Mexican-origin Hispanics also showed increased LVH and abnormal LV remodeling, even with lower hypertension rates.
- Acknowledging ethnic variations in LVH and LV remodeling is essential for precise cardiovascular risk stratification in Hispanic populations.
Objectives:
The purpose of this study was to examine the prevalence of left ventricular hypertrophy (LVH) and left ventricular (LV) remodeling patterns within Hispanic subgroups compared with non-Hispanic whites in the MESA (Multi-Ethnic Study of Atherosclerosis).
Background:
Hispanics are the largest and fastest-growing ethnic minority in the U.S., but there are no data on LVH and LV geometry among Hispanic subgroups.
Methods:
Cardiac magnetic resonance imaging was performed in 4,309 men and women age 45 to 84 years without clinical cardiovascular disease. Hispanics were categorized into subgroups based on self-reported ancestry. LVH was defined as the upper 95th percentile of indexed LV mass in a reference normotensive, nondiabetic, nonobese population, and LV remodeling according to the presence/absence of LVH and abnormal/normal LV mass to LV end-diastolic volume ratio.
Results:
Among Hispanic participants, 574 were of Mexican origin, 329 were of Caribbean origin, and 161 were of Central/South American origin. On unadjusted analysis, only Caribbean-origin Hispanics (prevalence ratio = 1.2; 95% confidence interval [CI]: 1.03 to 1.4) had greater prevalence of hypertension than non-Hispanic whites. Hispanic subgroups were more likely to have LVH than non-Hispanic whites after adjustment for hypertension and other covariates (Caribbean-origin Hispanics = odds ratio [OR]: 1.8, 95% CI: 1.1 to 3.0; Mexican-origin Hispanics = OR: 2.2, 95% CI: 1.4 to 3.3; Central/South Americans = OR: 1.5, 95% CI: 0.7 to 3.1). All Hispanic subgroups also had a higher prevalence of concentric and eccentric hypertrophy compared with non-Hispanic whites (p < 0.001).
Conclusions:
Caribbean-origin Hispanics had a higher prevalence of LVH and abnormal LV remodeling compared with non-Hispanic whites. A higher prevalence of LVH and abnormal LV remodeling was also observed among Mexican-origin Hispanics, despite a lower prevalence of hypertension. Differences among Hispanic subgroups regarding LVH and LV remodeling should be taken into account when evaluating cardiovascular risk in this population.
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