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Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement
Published on: March 26, 2018
Aortic valve replacement in octogenarians: identification of high-risk patients
Ines Florath1, Alexander Albert, Andreas Boening
1Heart Institute Lahr/Baden, Hohbergweg 2, D-77933 Lahr, Germany. ines.florath@mediclin.de
Insights
Surgical aortic valve replacement (AVR) is safe for most octogenarians. High-risk patients, identified by specific factors, have similar mortality rates to transcatheter aortic valve interventions.
Area of Science:
- Cardiovascular Surgery
- Geriatric Cardiology
- Interventional Cardiology
Background:
- Surgical aortic valve replacement (AVR) is a critical intervention for symptomatic aortic stenosis in octogenarians.
- Advances in transcatheter valve therapies necessitate clear patient selection criteria for surgical AVR.
Purpose of the Study:
- To identify high-risk octogenarians undergoing surgical AVR.
- To define patient selection criteria for AVR in the elderly population.
Main Methods:
- A retrospective analysis of 493 octogenarians who underwent AVR between 1996 and 2006.
- Multivariable logistic regression was used to determine risk factors for 6-month mortality.
Main Results:
- The 6-month mortality rate after AVR was 15.2%.
- Independent risk factors for mortality included age >84 years, ejection fraction <60%, BMI <24, elevated creatinine, and high blood glucose.
- High-risk groups (e.g., age >84 with EF <60%) experienced 28% 6-month mortality.
Conclusions:
- Surgical AVR is generally safe and effective in octogenarians.
- High-risk patients identified by STS score >10, EuroScore >20, or specific clinical factors (age, EF, BMI) show comparable mortality to transcatheter aortic valve interventions.
Objective:
This study identifies high-risk octogenarians for surgical aortic valve replacement (AVR) because with the current advances in transcatheter valve therapy, a definition of patient selection criteria is essential.
Methods:
Between 1996 and 2006, 493 consecutive octogenarians with symptomatic aortic stenosis underwent AVR with and without (51%) concomitant coronary artery bypass grafting (CABG). To identify high-risk patient groups, risk factors of 6-month mortality were determined using multivariable logistic regression.
Results:
The 30-day mortality rate was 8.4% and it increased up to 15.2% until 6 months after AVR. Independent risk factors of 6-month mortality were patients older than 84 years (odds ratio (OR): 2.2 (1.29-3.61)), left ventricular ejection fraction <60% (OR: 2.5 (1.35-4.61)), body mass index (BMI) <24 (OR: 2.0 (1.22-3.36)), creatinine (OR: 1.6 (1.04-2.53)) and blood glucose (OR: 1.01 (1.001-1.009)). High-risk groups were patients older than 84 years with an ejection fraction <60% (6-month mortality 28%) and patients younger than 84 years with an ejection fraction <60% and a BMI <24 (6-month mortality 23.2%). These high-risk groups comprised 37% of the patient population. After isolated AVR, the 30-day mortality and survival at 1 and 5 years was 11.6%, 69% and 35% in this high-risk group, respectively. In octogenarians with an STS score >10 and an EuroScore >20, the 30-day mortality and survival at 1 year was 10.5% and 80%, 11.6% and 77%, respectively.
Conclusions:
In most octogenarians, AVR is a safe and beneficial procedure. In high-risk octogenarians, identified by STS score >10, EuroScore >20 and by simple three risk factors (age >84 years, ejection fraction <60% and BMI <24), the mortality after surgical AVR was no different from the currently reported outcome after transcatheter AVI.
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