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Distinct ethnic differences in lipid profiles across glucose categories
Lei Zhang1, Qing Qiao, Jaakko Tuomilehto
1Department of Public Health, University of Helsinki, PL41, Mannerheimintie 172, FIN-00014 Helsinki, Finland.
The Journal of Clinical Endocrinology and Metabolism
|February 2, 2010
Summary
Ethnic differences in lipid profiles persist across varying glucose levels, highlighting the need for tailored cardiovascular disease prevention strategies. Asian Indians show higher low-density lipoprotein-cholesterol compared to Europeans, regardless of diabetes status.
Area of Science:
- Cardiovascular Health
- Metabolic Disorders
- Population Health
Background:
- Dyslipidemia frequently coexists with hyperglycemia, a common metabolic condition.
- Limited understanding exists regarding ethnic variations in lipid profiles when glucose tolerance is comparable.
Purpose of the Study:
- To investigate ethnic disparities in lipid profiles stratified by glucose levels.
- To identify ethnic-specific patterns in dyslipidemia.
Main Methods:
- Analysis of data from 31 study cohorts across 12 countries, involving 24,760 men and 27,595 women (aged 25-74).
- Estimation of odds ratios for dyslipidemia within each ethnic group, categorized by glucose tolerance status.
Main Results:
- Asian Indian men exhibited significantly higher odds of low high-density lipoprotein-cholesterol compared to central/northern Europeans across all glucose categories.
- Chinese men showed lower odds of low high-density lipoprotein-cholesterol compared to Europeans.
- Prevalence of low high-density lipoprotein-cholesterol remained higher in Asian Indians (62.8-67.4%) than in Europeans, Japanese, or Qingdao Chinese, even with controlled low-density lipoprotein-cholesterol levels.
Conclusions:
- Distinct ethnic patterns in lipid profiles are evident, irrespective of glucose levels.
- Ethnic-specific strategies are necessary for cardiovascular disease risk assessment and prevention.
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