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Association between joint hypermobility syndrome and panic disorder: a case-control study
Javier García Campayo1, Elena Asso, Marta Alda
1Dept. of Psychiatry, Miguel Servet University Hospital, University of Zaragoza, Zaragoza, Spain. jgarcamp@arrakis.es
Psychosomatics
|February 2, 2010
Summary
Joint hypermobility syndrome (JHS) is more common in people with panic disorder than in control groups. This suggests a potential genetic link between JHS and panic disorder.
Area of Science:
- Rheumatology
- Psychiatry
- Genetics
Background:
- A notable association exists between joint hypermobility syndrome (JHS) and panic disorder in rheumatology patients.
- This observation necessitates further investigation into the prevalence of JHS in individuals with panic disorder.
Purpose of the Study:
- To determine if joint hypermobility syndrome (JHS) is more prevalent in patients diagnosed with panic disorder compared to control subjects.
- To investigate the potential link between JHS and panic disorder.
Main Methods:
- A case-control study was performed.
- 55 untreated patients with panic disorder were compared against three matched control groups: psychiatric patients, fibromyalgia patients, and healthy individuals.
Main Results:
- Joint hypermobility syndrome (JHS) was found to be significantly more frequent in the panic disorder group than in the psychiatric, healthy, or fibromyalgia groups.
- A significant correlation was observed between the severity of JHS and anxiety levels within the panic disorder cohort.
Conclusions:
- The robust association between JHS and panic disorder suggests a possible genetic link.
- Further research may explore shared pathophysiological mechanisms between JHS, panic disorder, and mitral valve prolapse.
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