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Association between joint hypermobility syndrome and panic disorder: a case-control study
Javier García Campayo1, Elena Asso, Marta Alda
1Dept. of Psychiatry, Miguel Servet University Hospital, University of Zaragoza, Zaragoza, Spain. jgarcamp@arrakis.es
Background:
A significant association between joint hypermobility syndrome (JHS) and panic disorder was observed in a sample of rheumatology outpatients.
Objective:
The aim of this study was to assess whether JHS is more frequent in panic-disorder than in control subjects.
Method:
The authors conducted a case-control study comparing 55 untreated patients with panic disorder and three matched-control groups: psychiatric patients, fibromyalgia patients, and healthy persons.
Results:
JHS was more frequent among panic-disorder than among psychiatric patients, the healthy group, or the fibromyalgia group. In the panic-disorder group, there was a significant correlation between severity of JHS and anxiety.
Conclusion:
The strong association between JHS and panic disorder points to a genetic association. There is also a possibility that JHS and mitral valve prolapse, another condition frequently associated with panic disorder, share a common pathophysiological mechanism.
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