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11:09
EPA Method 1615. Measurement of Enterovirus and Norovirus Occurrence in Water by Culture and RT-qPCR. II. Total Culturable Virus Assay
Published on: September 11, 2016
Diseases caused by enterovirus 71 infection.
Ta-Chung Lee1, How-Ran Guo, Huey-Jen Jenny Su
1Department of Rehabilitation, Chiali General Hospital, Tainan, Taiwan.
The Pediatric Infectious Disease Journal
|February 2, 2010
Summary
Enterovirus 71 (EV71) causes severe hand-foot-mouth disease and herpangina, primarily in young children. Research highlights its epidemiology, pathogenesis, and the need for future vaccine development to combat this public health threat.
Area of Science:
- * Virology
- * Epidemiology
- * Public Health
Background:
- * Enterovirus 71 (EV71) is a significant pathogen causing hand-foot-mouth disease and herpangina.
- * Outbreaks are common, particularly in the Asia Pacific region, with seasonal peaks in summer.
- * EV71 infection poses a serious threat, especially to children under five, leading to severe neurological complications.
Purpose of the Study:
- * To review the epidemiology, pathogenesis, virology, and management of Enterovirus 71 (EV71) infections.
- * To understand the impact of EV71 on public health, particularly in the Asia Pacific region.
- * To identify knowledge gaps and recommend future research directions, including vaccine development.
Main Methods:
- * A comprehensive literature survey was conducted using Medline.
- * The keyword
- EV71
- was used to identify relevant published studies.
- * The review synthesized information on EV71's epidemiology, disease characteristics, and genetic diversity.
Main Results:
- * EV71 incidence shows annual and seasonal variations, peaking in summer.
- * Children under five are most vulnerable to severe complications, with the brainstem being a primary target.
- * Five genetic lineages (B3, B4, C1, C2, C4) of EV71 are circulating and evolving rapidly in the Asia Pacific region.
Conclusions:
- * Enterovirus 71 (EV71) infection is a major public health concern due to its potential for severe neurological sequelae.
- * The rapid evolution of EV71 strains necessitates ongoing surveillance and research.
- * Development of an EV71 vaccine is crucial for future prevention and control efforts.
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