Related Experiment Video
Updated: Jun 16, 2026

09:52
Genetic Manipulation in Δku80 Strains for Functional Genomic Analysis of Toxoplasma gondii
Published on: July 12, 2013
Novel molecular insights into the mechanism of GO removal by MutM
1Graduate Center for Toxicology, Markey Cancer Center, Department of Molecular & Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA. gmli@uky.edu
Cell Research
|February 2, 2010
Abstract
No abstract available in PubMed .
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Mismatch Repair
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
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Mismatch Repair
Overview
In-vitro Mutagenesis
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.

