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Related Experiment Videos

Serum melatonin during human pregnancy.

A Kivelä1

  • 1Department of Obstetrics and Gynecology, University of Oulu, Finland.

Acta Endocrinologica
|March 1, 1991
PubMed
Summary
This summary is machine-generated.

Serum melatonin levels increase significantly during the third trimester of pregnancy. This study found higher melatonin concentrations and an extended nocturnal rise in late pregnancy, suggesting altered synthesis or metabolism.

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Area of Science:

  • Endocrinology
  • Reproductive Biology
  • Chronobiology

Background:

  • Melatonin, a hormone regulating sleep-wake cycles, has potential roles in pregnancy.
  • Understanding melatonin's physiological changes during gestation is crucial for reproductive health research.

Purpose of the Study:

  • To investigate serum melatonin concentrations in pregnant women across different trimesters and compare them to non-pregnant controls.
  • To analyze the diurnal rhythm and nocturnal patterns of melatonin secretion during early and late pregnancy.

Main Methods:

  • Radioimmunoassay measurement of serum melatonin in 55 pregnant women (trimesters 1, 2, 3) and 11 non-pregnant controls (Study A).
  • Serial blood sampling every four hours over 24 hours in early (12 women) and late (11 women) pregnancy (Study B).

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Main Results:

  • Third-trimester melatonin levels (76.5 pmol/l) were significantly higher (p<0.01) than in the first (29.7 pmol/l), second (39.1 pmol/l) trimesters, and controls (41.7 pmol/l).
  • A positive correlation was observed between gestational week and 11:00 h serum melatonin (Study A).
  • A distinct diurnal rhythm of melatonin was present in both early and late pregnancy, with an increased amplitude and duration of nocturnal rise in late pregnancy (Study B).

Conclusions:

  • Serum melatonin concentrations significantly increase in the third trimester of pregnancy.
  • Late pregnancy is characterized by an enhanced nocturnal melatonin surge, possibly due to increased production or reduced metabolism.
  • Melatonin secretion patterns change during pregnancy, warranting further investigation into its specific roles.