Related Experiment Video

Updated: Jun 16, 2026

Confocal Microscopy Reveals Cell Surface Receptor Aggregation Through Image Correlation Spectroscopy
06:51

Confocal Microscopy Reveals Cell Surface Receptor Aggregation Through Image Correlation Spectroscopy

Published on: August 2, 2018

Selectivity and noise effects in applications of optical correlation

F M Shofner, R O Webb

    Applied Optics
    |February 2, 2010
    PubMed

    More Related Videos

    A Photonic System for Generating Unconditional Polarization-Entangled Photons Based on Multiple Quantum Interference07:56

    A Photonic System for Generating Unconditional Polarization-Entangled Photons Based on Multiple Quantum Interference

    Published on: September 5, 2019

    A Fluorescence Fluctuation Spectroscopy Assay of Protein-Protein Interactions at Cell-Cell Contacts08:43

    A Fluorescence Fluctuation Spectroscopy Assay of Protein-Protein Interactions at Cell-Cell Contacts

    Published on: December 1, 2018

    Related Concept Videos

    Difference from Background: Limit of Detection01:05

    Difference from Background: Limit of Detection

    The limit of detection (LOD) is the smallest amount of analyte that can be distinguished from the background noise. The LOD value corresponds to the concentration at which the analyte signal is three times larger than the standard deviation of the blank signal. Below this value, the analyte signal cannot be differentiated from the background noise. It is calculated by dividing the calibration slope by 3 times the standard deviation of the blank signals.
    The LOD indicates the presence or absence...
    2D NMR: Overview of Heteronuclear Correlation Techniques01:18

    2D NMR: Overview of Heteronuclear Correlation Techniques

    Heteronuclear correlation spectroscopy is an analytical technique that investigates the coupling between different types of nuclei, often a proton and an X-nucleus, such as carbon-13 or nitrogen-15. This method is commonly used in nuclear magnetic resonance (NMR) spectroscopy to gain insights into complex chemical compounds' structural and compositional aspects. A typical heteronuclear correlation spectrum displays X-nucleus chemical shifts on one axis and a proton spectrum on the other axis.
    2D NMR: Overview of Homonuclear Correlation Techniques01:16

    2D NMR: Overview of Homonuclear Correlation Techniques

    Homonuclear correlation spectroscopy (COSY) is a powerful technique used in Nuclear Magnetic Resonance (NMR) spectroscopy to study the correlations between nuclei of the same type within a molecule. It provides information about scalar couplings between adjacent nuclei, which helps determine connectivity and structural information. There are several COSY variants, each with its unique strengths and experimental parameters.
    COSY90 is the standard two-dimensional (2D) COSY experiment that...
    Drug Concentration Versus Time Correlation01:15

    Drug Concentration Versus Time Correlation

    The plasma drug concentration-time curve is a crucial tool in pharmacokinetics, representing the drug's concentration in plasma at different time intervals post-administration. This curve illustrates the drug's journey from absorption into the systemic circulation, distribution to body tissues, and eventual elimination through excretion or biotransformation.
    Two pivotal parameters are the minimum effective concentration (MEC) and the minimum toxic concentration (MTC). The MEC is the lowest drug...
    Calibration Curves: Correlation Coefficient01:10

    Calibration Curves: Correlation Coefficient

    In a linear calibration curve, there is a value called the calibration coefficient, denoted by 'r,' which measures the strength and the direction of association between two variables. The correlation coefficient value ranges from −1 to +1. A value of +1 indicates a perfect positive linear correlation, −1 denotes a perfect negative correlation, and 0 implies no correlation between the two variables. A positive correlation value establishes that as one variable increases, the other increases, and...
    Dose-Response Relationship: Selectivity and Specificity01:25

    Dose-Response Relationship: Selectivity and Specificity

    Drugs exert their therapeutic effects by interacting with receptors, enzymes, or ion channels that are present throughout the human body. The strength and duration of the interaction between a drug and its target receptor are characterized by the selectivity and specificity of the drug. Selectivity refers to a drug's strong preference for its intended target over other targets. For instance, isoprenaline, a non-selective β-adrenergic agonist, interacts with both β1- and β2-adrenergic receptors...