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Updated: Jun 16, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Ventricular function and all-cause mortality in chronic kidney disease patients with angiographic coronary artery

I-Wen Wu1, Ming-Jui Hung, Yung-Chang Chen

  • 1Department of Nephrology, Keelung Chang Gung Memorial Hospital, Taipei; and College of Medicine, Chang Gung University, Taipei - Taiwan.

Journal of Nephrology
|February 2, 2010
PubMed

Insights

Low left ventricular ejection fraction (LVEF) is linked to chronic kidney disease (CKD) and predicts mortality in CKD patients, even those without coronary artery disease (CAD). This finding highlights LVEF as a critical prognostic factor.

Area of Science:

  • Cardiology
  • Nephrology
  • Public Health

Background:

  • Coronary artery disease (CAD) and chronic kidney disease (CKD) are significant contributors to morbidity and mortality.
  • CKD patients face risks of myocardial ischemia, chamber abnormalities, and reduced left ventricular ejection fraction (LVEF) due to various factors.
  • The prognostic value of LVEF in relation to mortality in non-dialysis CKD patients with suspected myocardial ischemia is not well-established.

Purpose of the Study:

  • To investigate the association between LVEF and CKD stages.
  • To determine the relationship between LVEF and all-cause mortality in CKD patients.
  • To assess the prognostic significance of LVEF in CKD patients with and without angiographic CAD.

Main Methods:

  • Retrospective analysis of 980 CKD patients undergoing coronary angiography (1995-2004).
  • Assessment of demographic, clinical data, and ventriculographic LVEF.
  • Application of Cox proportional hazard regression models for risk estimation.

Main Results:

  • 45.4% of CKD patients had angiographic CAD; LVEF, hemoglobin, and BMI decreased with declining eGFR.
  • Low LVEF was independently associated with CKD, irrespective of age, sex, diabetes, hypertension, BMI, hemoglobin, and CAD presence.
  • Independent predictors of mortality included diabetes, BMI, hemoglobin, and LVEF. Low LVEF was the sole independent predictor in CKD patients with angiographic CAD.

Conclusions:

  • Reduced LVEF is independently associated with CKD.
  • Low LVEF serves as an independent predictor of mortality in CKD patients, regardless of angiographic CAD status.
Abstract

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