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Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
Diphtheria01:28

Diphtheria

Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...
Rocky Mountain Spotted Fever01:26

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
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Related Experiment Video

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Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy
10:55

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy

Published on: October 31, 2025

Minocycline-induced dermatomyositis.

Maiya R Geddes1, Michael Sinnreich, Colin Chalk

  • 1Department of Neurology, McGill University, Room L7-313, 1650 Cedar Avenue, Montreal, Quebec, H3G 1A4 Canada.

Muscle & Nerve
|February 2, 2010
PubMed
Summary
This summary is machine-generated.

Minocycline, a tetracycline antibiotic, can trigger autoimmune reactions. A patient developed panniculitis and dermatomyositis during minocycline treatment for acne, with symptoms resolving after drug discontinuation.

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Published on: October 31, 2025

Area of Science:

  • Dermatology
  • Rheumatology
  • Pharmacology

Background:

  • Minocycline is a widely prescribed semisynthetic tetracycline antibiotic.
  • Tetracyclines, including minocycline, are known to cause various autoimmune adverse reactions.
  • Acne vulgaris is a common dermatological condition often treated with minocycline.

Observation:

  • A previously healthy patient developed skin and muscle inflammation during minocycline therapy for acne.
  • The patient presented with panniculitis (inflammation of subcutaneous fat) and dermatomyositis (inflammation of muscles and skin).
  • Histopathological examination confirmed the diagnosis of dermatomyositis.

Findings:

  • Minocycline treatment was associated with the onset of panniculitis and dermatomyositis.
  • Discontinuation of minocycline led to complete resolution of the patient's signs and symptoms.
  • This case suggests a potential novel autoimmune adverse effect of minocycline.

Implications:

  • This case highlights the importance of considering minocycline as a potential cause of drug-induced autoimmune conditions.
  • Physicians should be aware of this potential adverse reaction when prescribing minocycline, especially for long-term use.
  • Further research may be warranted to elucidate the mechanisms underlying minocycline-induced autoimmunity.