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Related Experiment Video

Updated: Jun 16, 2026

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

Krukenberg's tumour.

M S Mijinyawa¹, M U Sani, S M Yusuf

¹Department of Medicine, Aminu Kano Teaching Hospital P.M.B. 3452, Kano, Nigeria. msanim2000@yahoo.com

Nigerian Journal of Medicine : Journal of the National Association of Resident Doctors of Nigeria

|February 3, 2010

Summary

This summary is machine-generated.

Krukenburg tumor (KT) diagnosis is challenging, especially in women with a history of gastrointestinal cancer. Regular monitoring is crucial for early detection and management of ovarian metastasis.

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Area of Science:

Oncology
Gastroenterology
Gynecologic Oncology

Background:

Krukenburg tumor, a rare ovarian metastasis, presents diagnostic challenges.
Metastatic gastric cancer to the ovary requires careful consideration in differential diagnosis.

Observation:

A 32-year-old female presented with gastrointestinal and gynecologic symptoms 2 years post-gastric cancer surgery.
Clinical presentation included diarrhea, menstrual irregularities, weight loss, and abdominal pain.

Findings:

Elevated CEA levels, sigmoid colon mass (signet ring cell carcinoma), and bilateral adnexal masses confirmed metastatic disease.
Histopathology revealed metastatic adenocarcinoma in the ovaries, consistent with Krukenburg tumor.

Implications:

Highlights the difficulty in early Krukenburg tumor diagnosis.
Emphasizes the need for periodic surveillance in patients with a history of gastrointestinal malignancy.