Related Experiment Video
Updated: Jun 16, 2026

Modeling Charcot-Marie-Tooth Disease In Vitro by Transfecting Mouse Primary Motoneurons
Published on: January 7, 2019
Small fiber neuropathy in Charcot-Marie-Tooth disease
1EMG Laboratory, Department of Neurology, University of Athens, Aeghinition Hospital, Athens, Greece. tzabelis@med.uoa.gr
Unlabelled:
The aim of this study was to investigate small myelinated (Adelta) and unmyelinated (C) fiber function in patients with CMT1A and CMTX polyneuropathy. 17 CMT1A and 10 Cx32 polyneuropathy patients were investigated with warm and cold threshold to evaluate small myelinated (Adelta) an unmyelinated (C) somatic fiber function and with sympathetic skin responses (SSR) to evaluate postganglionic sympathetic fiber function. Median age and disease duration did not differ between the two groups. Charcot-Marie-Tooth neuropathy score was higher in CMTX patients. Mean MCV differed significantly between the two groups in both Median and Ulnar nerve. In CMT1A patients warm threshold was abnormal in 72% and cold threshold in 53%. On the contrary, in Cx32 patients group warm and cold threshold was abnormal in 10 and 20% respectively. SSR was also abnormal in only a small number of both CMT1A and Cx32 patients (24% and 10% respectively).
Conclusion:
Small fiber function is frequently impaired in CMT1A polyneuropathy patients.
More Related Videos
11:29Corneal Confocal Microscopy: A Novel Non-invasive Technique to Quantify Small Fibre Pathology in Peripheral Neuropathies
Published on: January 3, 2011
09:39Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
Published on: February 13, 2018
Related Concept Videos
Diabetic Neuropathy
Diabetic Foot Ulcer
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Local Anesthetics: Differential Sensitivity of Nerve Fibers
Peripheral Artery Disease I: Introduction
Myasthenia Gravis ll: Pathophysiology