A two eterochronous primary gynaecological malignancies of different origin

The objective of our study is to present a rare case of two eterochronous primary gynaecological malignancies.

A 65-year-old para-2, white obese female, presented in our department 4 years ago, due to a single event of vaginal spotting. Curettage revealed an endometrial cancer. A total abdominal hysterectomy and bilateral salpingo-oophorectomy was performed. Histology showed an endometrioid adenocarcinoma of endometrium stage Ib, moderately differentiated. No additional therapy was given. Twenty seven months later, a pathologic Papanicolaou smear came out on her routine follow-up. Although, recurrence on vaginal cuff was possible, the biopsies of anterior vaginal wall showed a poorly differentiated squamous cell carcinoma of the vagina. An exploratory laparotomy was performed, but tumor resection was not possible. The patient was classified as stage II vaginal carcinoma and underwent complete radiotherapy and chemotherapy.

This case indicates that female genital carcinomas of different histological origins may occur with minimal time-interval, even in the absence of known predisposing factors like previous chemo-radiotherapy, HPV infection or diethylstilbestrol exposure. The role of close follow up of hysterectomised patients should also be mentioned (Fig. 1, Ref. 15). Full Text (Free, PDF) www.bmj.sk.