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Age-related osteoporosis.

¹Dept. of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-8889.

The American Journal of the Medical Sciences

|April 1, 1991

Summary

This summary is machine-generated.

Osteoporosis affects millions, causing fractures and significant costs. This review examines age-related bone changes and treatment options like calcium and estrogen for elderly patients.

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Area of Science:

Gerontology
Bone Physiology
Pharmacology

Background:

Osteoporosis is a prevalent condition leading to substantial morbidity, mortality, and financial burden, with 1.2 million fractures annually in the U.S.
Current research often overlooks age-related differences, focusing primarily on early postmenopausal individuals.
Significant epidemiologic, physiologic, and clinical distinctions exist between early postmenopausal women and older individuals.

Purpose of the Study:

To review age-related changes in bone physiology pertinent to osteoporosis.
To evaluate the evidence for commonly used and approved osteoporosis treatments in the elderly population.

Main Methods:

Literature review focusing on age-related bone physiology.
Analysis of studies evaluating calcium, estrogen, and calcitonin in older adults.

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Main Results:

Age-related bone physiology differs significantly from that in younger individuals.
Evidence for the efficacy and safety of certain osteoporosis treatments in the elderly requires careful consideration.

Conclusions:

Generalizing treatment recommendations from younger to older patients with osteoporosis may not be appropriate.
Further research is needed to optimize osteoporosis management in the elderly, considering specific age-related factors.