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Published on: November 30, 2022
Stereospecific Suzuki cross-coupling of alkyl alpha-cyanohydrin triflates
1Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Abstract:
Scalemic alpha-cyanohydrin triflates undergo Pd-catalyzed cross-coupling with aryl, heteroaryl, and vinyl boronic acids under mild conditions. Coupling proceeds with complete inversion of configuration at the stereogenic carbon. The resultant nitrile can be easily converted into a variety of alternative functional groups of value in organic synthesis and thus achieves a higher level of molecular complexity than the products of traditional Suzuki reactions.
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