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Updated: Jun 16, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
08:03

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Published on: November 4, 2025

Incidence of perinatal complications in children with premature craniosynostosis

Benedikt Weber1, Anton H Schwabegger, Wilhelm Oberaigner

  • 1Clinical Department of Plastic and Reconstructive Surgery, Innsbruck Medical University, Innsbruck, Austria.

Journal of Perinatal Medicine
|February 4, 2010
PubMed

Insights

Children with craniosynostosis face higher rates of birth complications, including abnormal presentations and lower Apgar scores. This study highlights increased risks for infants diagnosed with craniosynostosis.

Area of Science:

  • Pediatrics
  • Obstetrics
  • Medical Genetics

Background:

  • Craniosynostosis is a condition involving premature fusion of skull sutures.
  • Perinatal complications can impact infant outcomes.
  • Understanding these risks is crucial for clinical management.

Purpose of the Study:

  • To investigate the incidence of perinatal complications in infants with craniosynostosis.
  • To compare complication rates in craniosynostosis cases with a general birth population.

Main Methods:

  • A retrospective study involving questionnaires sent to mothers of children diagnosed with craniosynostosis.
  • Comparison of complication data with the Birth Registry of Tyrol.
  • Statistical analysis to determine significant differences.

Main Results:

  • Infants with craniosynostosis exhibited significantly higher rates of fetal malpresentations (abnormal cephalic and breech presentations).
  • Lower Apgar scores and pH values were observed in neonates with craniosynostosis compared to controls.
  • A total of 102 questionnaires were returned, representing a 46.4% response rate.

Conclusions:

  • Craniosynostosis is associated with a significantly increased incidence of various birth complications.
  • These findings underscore the need for vigilant monitoring and management of pregnancies and deliveries involving infants with craniosynostosis.
Abstract

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