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Related Experiment Video

Updated: Jun 16, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Systemic lupus erythematosus and pregnancy.

R Madazli¹, B Bulut, H Erenel

¹Department of Obstetrics and Gynecology, Istanbul University, Istanbul, Turkey. madazli@superonline.com

Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology

|February 4, 2010

Summary

Pregnancy in women with systemic lupus erythematosus (SLE) can lead to complications. Uterine artery Doppler abnormalities are linked to poorer outcomes, highlighting the need for multidisciplinary care.

Related Experiment Videos

Last Updated: Jun 16, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Area of Science:

Obstetrics and Gynecology
Rheumatology
Maternal-Fetal Medicine

Background:

Systemic lupus erythematosus (SLE) in pregnancy presents unique challenges for both mother and fetus.
Understanding risk factors and outcomes is crucial for optimizing care during pregnancy for women with SLE.

Purpose of the Study:

To evaluate obstetric outcomes in a cohort of pregnant women with SLE.
To identify factors influencing maternal and fetal well-being in SLE pregnancies.
To assess the prognostic value of uterine artery Doppler and antiphospholipid antibodies.

Main Methods:

Retrospective study of 42 consecutive SLE pregnancies between 2002-2007.
Analysis of patient demographics, disease activity, antibody status, and obstetric complications.
Inclusion of uterine artery Doppler findings in outcome assessment.

Main Results:

Mean gestational age was 36.9 weeks; mean birth weight was 2,750g.
Rates of stillbirth (7.1%), fetal growth restriction (14.3%), and preterm delivery (23.1%) were observed.
Uterine artery Doppler abnormalities correlated significantly with adverse obstetric outcomes.
Antiphospholipid antibodies, renal involvement, and lupus activity did not significantly impact outcomes.

Conclusions:

A multidisciplinary approach is essential for managing SLE pregnancies.
Uterine artery Doppler is a valuable prognostic indicator for adverse outcomes in SLE pregnancies.
Early identification and management of risk factors can improve maternal and fetal health.