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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...

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Therapeutic Massage for Psychological Well-being in Geriatric Oncology
03:59

Therapeutic Massage for Psychological Well-being in Geriatric Oncology

Published on: May 22, 2026

Geriatric assessment in oncology practice.

Arti Hurria1

  • 1Department of Medical Oncology and Therapeutics Research, City of Hope, Duarte, CA 91010, USA. ahurria@coh.org

Journal of the American Geriatrics Society
|February 4, 2010
PubMed
Summary
This summary is machine-generated.

Chronological age is insufficient for older adults with cancer. A comprehensive geriatric assessment can identify vulnerabilities and optimize cancer care for this growing population.

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Area of Science:

  • Geriatric oncology
  • Cancer survivorship
  • Health services research

Background:

  • Chronological age is a poor proxy for the diverse health status of older adults with cancer.
  • A standardized tool for assessing functional age in this population is lacking.
  • Geriatric assessment (GA) offers a comprehensive evaluation of factors impacting health and longevity.

Purpose of the Study:

  • To highlight the utility of geriatric assessment in oncology.
  • To review existing data supporting the benefits of GA in older cancer patients.
  • To advocate for the integration of GA into routine oncology care and research.

Main Methods:

  • Review of literature on geriatric assessment in oncology.
  • Analysis of data demonstrating the benefits of GA.
  • Discussion of challenges and opportunities for integrating GA into clinical practice.

Main Results:

  • Geriatric assessment evaluates functional status, comorbidity, cognition, psychological state, nutrition, and social support.
  • GA identifies individual vulnerabilities and predicts morbidity and mortality.
  • Evidence suggests GA improves outcomes and informs targeted interventions.

Conclusions:

  • Integrating geriatric assessment into oncology is crucial for personalized care.
  • Further research is needed to optimize GA implementation in cancer settings.
  • This approach can lead to better cancer outcomes for older adults.