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Pre-mRNA Processing: RNA Splicing01:32

Pre-mRNA Processing: RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
Pre-mRNA Processing: Modification of pre-mRNA Ends01:35

Pre-mRNA Processing: Modification of pre-mRNA Ends

In eukaryotic cells, transcripts made by RNA polymerase are modified and processed before exiting the nucleus. Unprocessed RNA is called precursor mRNA or pre-mRNA to distinguish it from mature mRNA.
Once about 20-40 ribonucleotides have been joined together by RNA polymerase, a group of enzymes adds a cap to the 5' end of the growing transcript. In this process, a 5' phosphate is replaced by modified guanosine that has a methyl group attached (7-methyl guanosine). This 5' cap helps the cell...

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Related Experiment Video

Updated: Jun 16, 2026

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data
08:35

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data

Published on: June 24, 2021

Discrete wavelet transform de-noising in eukaryotic gene splicing.

Tina P George1, Tessamma Thomas

  • 1Department of Electronics and Instrumentation, College of Engineering, Kidangoor, Kottayam, Kerala, India. tinapgcusat@gmail.com

BMC Bioinformatics
|February 4, 2010
PubMed
Summary
This summary is machine-generated.

This study enhances exon prediction in eukaryotes using digital signal processing and proposes a novel noise suppression technique. Discrete wavelet transform effectively denoises exon plots, improving prediction accuracy for medical research applications.

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Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • Exon prediction is crucial for understanding eukaryotic gene structure.
  • Digital signal processing (DSP) methods offer powerful tools for genomic sequence analysis.
  • Genomic data from public databases like GenBank is essential for validating computational methods.

Purpose of the Study:

  • To compare common DSP methods for eukaryotic exon prediction.
  • To introduce a noise suppression technique for enhanced exon prediction.
  • To validate findings using data relevant to medical research.

Main Methods:

  • Comparison of binary, EIIP (electron-ion interaction pseudopotential), and filter methods for exon prediction.
  • Implementation of two filter designs with two distinct approaches.
  • Application of discrete wavelet transform for de-noising exon plots.

Main Results:

  • Exon prediction results were obtained and compared against NCBI database values.
  • The proposed noise suppression technique using discrete wavelet transform was applied.
  • The de-noised exon plots demonstrated improved data quality.

Conclusions:

  • Modified DSP methods significantly improve exon prediction algorithm performance.
  • Discrete wavelet transform is an effective tool for de-noising in exon prediction pipelines.
  • The enhanced methods provide more accurate genomic sequence analysis for medical applications.