Disseminated zygomycosis in a cynomolgus monkey (Macaca fascicularis)

Here we describe a case of zygomycosis in a 4-y-old male cynomolgus monkey (Macaca fascicularis) newly received into our facility. Results of physical exam, clinical chemistry analysis, hematology, and tuberculin skin testing and routine thoracic radiographs performed during the quarantine period are reported. Routine chest radiographs taken during the quarantine period revealed enlargement of the cranial mediastinum. During quarantine, the macaque developed severe respiratory distress and was euthanized. Microscopic examination of tissue collected at the postmortem exam revealed nonseptated, branching hyphae in sections of the stomach and mediastinal lymph nodes consistent with a zygomycete. This is the first reported case of zygomycosis in a cynomolgus monkey.