Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dynamic strength of iron under pressure-temperature conditions of Earth's inner core.

Nature communications·2026
Same author

Effect of cigarette smoke on surface roughness and bacterial adhesion of orthodontic aligners: an in vitro investigation.

Clinical oral investigations·2026
Same author

Adhesive Wear Assessment of the Prosthetic Abutment and Detorque Values of Conical Connection Implants with Different Conicities.

The International journal of oral & maxillofacial implants·2025
Same author

Effect of cigarette smoke on the optical properties of clear orthodontic aligners: an in-vitro study.

Journal of orthodontics·2025
Same author

Oligomeric HIV-1 integrase structures reveal functional plasticity for intasome assembly and RNA binding.

Nature communications·2025
Same author

Deformation Behaviors in Single BCC-Phase Refractory Multi-Principal Element Alloys under Dynamic Conditions.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025

Related Experiment Video

Updated: Jun 16, 2026

Sequential In vivo Imaging of Osteogenic Stem/Progenitor Cells During Fracture Repair
10:30

Sequential In vivo Imaging of Osteogenic Stem/Progenitor Cells During Fracture Repair

Published on: May 23, 2014

Sequential bone healing of immediately loaded mini-implants: histomorphometric and fluorescence analysis.

Glaucio Serra1, Liliane S Morais, Carlos Nelson Elias

  • 1Department of Mechanical and Aerospace Engineering, University of California-San Diego, USA. gserrag@hotmail.com

American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics
|February 4, 2010
PubMed
Summary

Immediate loading of orthodontic mini-implants with 1 N force did not compromise bone healing in rabbits. Bone formation and contact increased over time, with no significant differences between loaded and unloaded groups at early stages.

More Related Videos

A Minimally Invasive Model to Analyze Endochondral Fracture Healing in Mice Under Standardized Biomechanical Conditions
06:41

A Minimally Invasive Model to Analyze Endochondral Fracture Healing in Mice Under Standardized Biomechanical Conditions

Published on: March 22, 2018

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance
06:54

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance

Published on: February 13, 2026

Related Experiment Videos

Last Updated: Jun 16, 2026

Sequential In vivo Imaging of Osteogenic Stem/Progenitor Cells During Fracture Repair
10:30

Sequential In vivo Imaging of Osteogenic Stem/Progenitor Cells During Fracture Repair

Published on: May 23, 2014

A Minimally Invasive Model to Analyze Endochondral Fracture Healing in Mice Under Standardized Biomechanical Conditions
06:41

A Minimally Invasive Model to Analyze Endochondral Fracture Healing in Mice Under Standardized Biomechanical Conditions

Published on: March 22, 2018

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance
06:54

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance

Published on: February 13, 2026

Area of Science:

  • Orthodontics
  • Biomaterials Science
  • Dental Implantology

Background:

  • Orthodontic mini-implants are frequently subjected to immediate loading.
  • Early loading may impact interfacial tissue healing and implant function.
  • Understanding the effects of immediate loading on bone healing is crucial for treatment success.

Purpose of the Study:

  • To evaluate interfacial tissue healing around titanium-alloy mini-implants.
  • To compare healing at 1, 4, and 12 weeks post-placement.
  • To assess the impact of immediate loading versus no loading on bone regeneration.

Main Methods:

  • Titanium grade 5 mini-implants were placed in New Zealand rabbits.
  • Two implants per animal were immediately loaded with 1 N force; others were unloaded.
  • Tissue healing and calcium deposition were analyzed using microscopy at 1, 4, and 12 weeks.

Main Results:

  • Bone contact and bone area increased significantly from 1 to 12 weeks, irrespective of loading.
  • No significant differences in bone healing were observed between loaded and unloaded groups at 1 and 4 weeks.
  • A higher bone deposition rate was noted in the immediately loaded group.

Conclusions:

  • Immediate application of 1 N force does not impede bone formation around orthodontic mini-implants.
  • Early loading of mini-implants appears safe for bone integration.
  • Findings support the feasibility of immediate loading protocols in orthodontics.