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[Hyperparathyroidism in deficiency rickets. Changes after vitamin therapy].

E Mallet, S Bousnina, P Tron

Archives Francaises De Pediatrie

|August 1, 1977

Summary

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In deficiency rickets, serum parathyroid hormone (IPTH) levels rise in late stages but normalize with vitamin D therapy. Urinary cyclic adenosine monophosphate excretion parallels IPTH changes.

Area of Science:

Pediatric Endocrinology
Nutritional Biochemistry

Context:

Rickets is a significant pediatric skeletal disorder.
Understanding parathyroid hormone (IPTH) dynamics in rickets is crucial for diagnosis and management.

Purpose:

To investigate the relationship between serum parathyroid hormone (IPTH) levels and biochemical markers in deficiency rickets.
To assess the impact of vitamin D therapy on IPTH levels and urinary cyclic adenosine monophosphate excretion.

Summary:

This study analyzed 16 cases of deficiency rickets over three years.
Elevated IPTH was observed in late-stage rickets, while early stages sometimes showed normal IPTH with hypocalcemia and monophosphatemia.
No significant correlation was found between IPTH and either serum calcium or monophosphate levels.

Related Experiment Videos

Vitamin D therapy (D2 or 25 OH D) normalized IPTH in most cases within 5-21 days.

Urinary cyclic adenosine monophosphate excretion decreased in parallel with blood IPTH levels post-treatment.

Impact:

Provides insights into the hormonal response in rickets.
Highlights the efficacy of vitamin D therapy in normalizing IPTH.
Suggests urinary cyclic adenosine monophosphate as a potential marker related to IPTH activity in rickets.