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Updated: Jun 16, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Colestimide, an anion exchange resin agent, can decrease the number of LDL particles without affecting their size in

Noriaki Kishimoto¹, Satoshi Fujii, Hitoshi Chiba

¹Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Journal of Cardiology

|February 4, 2010

Summary

Colestimide treatment in hyperlipidemia patients reduced low-density lipoprotein (LDL) particle numbers but did not alter LDL particle size. This suggests a potential benefit in managing arteriosclerosis risk factors.

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Area of Science:

Cardiovascular Science
Pharmacology
Lipid Metabolism

Background:

Arteriosclerosis development is linked to both plasma low-density lipoprotein (LDL) levels and the quantity of small, dense LDL particles.
Anion exchange resins can lower plasma LDL and influence LDL particle size by elevating triglycerides.

Purpose of the Study:

To investigate the impact of short-term colestimide administration on LDL particle size in patients with hyperlipidemia.

Main Methods:

Twenty-one obese patients with primary hyperlipidemia received 3000 mg/day of colestimide for one month.
Fasting blood samples were analyzed pre- and post-treatment using nuclear magnetic resonance (NMR) lipoprofile to measure LDL particle size and number.

Main Results:

Colestimide significantly reduced LDL cholesterol and apolipoprotein B levels.
While LDL particle size remained unchanged, there was a significant decrease in LDL particle numbers.
High-density lipoprotein (HDL) cholesterol and triglyceride levels were unaffected.

Conclusions:

Short-term colestimide administration effectively decreased LDL particle numbers in hyperlipidemia patients.
Colestimide did not alter LDL particle size during the study period.