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Related Experiment Video

Updated: Jun 16, 2026

The Influence of Liver Resection on Intrahepatic Tumor Growth
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The Influence of Liver Resection on Intrahepatic Tumor Growth

Published on: April 9, 2016

Is cell salvage safe in liver resection? A pilot study.

Annette Schmidt1, Harald C Sues, Ekkehard Siegel

  • 1Department of Anesthesiology, Johannes Gutenberg-University, Mainz, Germany.

Journal of Clinical Anesthesia
|February 4, 2010
PubMed
Summary

Cell salvaged (CS) blood used in liver resection appears safe regarding cytokine and complement activation. Further research is needed to assess bacterial contamination risks in CS blood for hemihepatectomy patients.

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Area of Science:

  • Anesthesiology and Perioperative Medicine
  • Transfusion Medicine
  • Surgical Research

Background:

  • Cell salvage (CS) is a technique used to reinfuse a patient's own blood lost during surgery.
  • The quality and safety of CS blood, particularly concerning inflammatory markers and bacterial contamination, require thorough evaluation, especially in complex procedures like hemihepatectomy.

Purpose of the Study:

  • To assess the quality of CS blood in patients undergoing hemihepatectomy.
  • To compare the quality of CS blood from hemihepatectomy with that from aortic surgery.

Main Methods:

  • An observational study was conducted in an operating room setting.
  • Blood samples were collected from 6 patients (hemihepatectomy and aortic surgery) with significant blood loss (>800 mL).

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Last Updated: Jun 16, 2026

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  • Analysis included cytokine levels (IL-6, IL-8, IL-10, TNF), complement activation markers (C3a, C5b-9), and microbiological assessment.

    • Main Results:

    • In hemihepatectomy patients, CS blood reservoir levels of IL-6, C3a, and C5b-9 were higher than central venous catheter samples.
    • Post-washing, these markers decreased in liver resection patients' CS blood compared to their plasma.
    • Microbiological analysis revealed sterile or low-level commensal flora in most samples, with one case of potential intestinal flora contamination in the liver resection group.

    Conclusions:

    • CS blood in liver resection appears safe concerning cytokine release and complement activation.
    • Further investigation is warranted to fully understand the risks of bacterial contamination in CS blood used for hemihepatectomy.