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Updated: Jun 16, 2026

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier (MSC) for Lung Cancer Screening

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier (MSC) for Lung Cancer Screening

Published on: October 26, 2017

Lung cancer screening--are we there yet?

Eiran Warner¹, Alan Jotkowitz, Nimrod Maimon

¹Medical School for International Health, Ben-Gurion University of Negev in collaboration with Columbia University Medical Center, Beer-Sheva, Israel.

European Journal of Internal Medicine

|February 4, 2010

Summary

Lung cancer screening using computed tomography shows promise, but definitive evidence of reduced mortality is still lacking. Large randomized trials are needed to confirm the benefits of lung cancer screening.

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Last Updated: Jun 16, 2026

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier (MSC) for Lung Cancer Screening

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier (MSC) for Lung Cancer Screening

Published on: October 26, 2017

Area of Science:

Oncology
Radiology
Public Health

Background:

Lung cancer is a leading cause of cancer death, often linked to smoking.
Early detection improves prognosis, yet current guidelines do not recommend routine screening due to insufficient evidence.
Advances in screening technology, like computed tomography, offer new possibilities.

Purpose of the Study:

To review the rationale for lung cancer screening.
To evaluate past screening studies and their limitations.
To summarize current knowledge and ongoing trials in lung cancer screening.

Main Methods:

A comprehensive literature search was performed using Medline from 1966 onwards.
Keywords included "lung cancer screening," "chest X-ray," "low-dose computed tomography," and "cancer screening guidelines."
Relevant references were also identified from bibliographies of key articles.

Main Results:

Older screening methods like chest X-ray and sputum analysis yielded negative results.
Recent uncontrolled studies using chest computed tomography scans have shown encouraging outcomes.
Randomized controlled trials for computed tomography screening have recently commenced.

Conclusions:

While preliminary results are promising, the definitive benefit of lung cancer screening remains uncertain.
Robust data from large, well-designed randomized controlled trials are essential to overcome research biases.
Current evidence does not support routine lung cancer screening, pending further research.