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Related Concept Videos

Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...

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Related Experiment Video

Updated: Jun 16, 2026

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
06:54

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion

Published on: June 15, 2019

HMGA and cancer.

Monica Fedele1, Alfredo Fusco

  • 1Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli "Federico II", via Pansini 5, 80131 Naples, Italy.

Biochimica Et Biophysica Acta
|February 4, 2010
PubMed
Summary

High Mobility Group A (HMGA) proteins are key cancer drivers, frequently overexpressed in malignancies and rearranged in benign tumors. Targeting HMGA offers a promising avenue for novel cancer therapies.

Related Experiment Videos

Last Updated: Jun 16, 2026

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
06:54

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion

Published on: June 15, 2019

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • High Mobility Group A (HMGA) proteins are widely expressed cancer-associated proteins.
  • HMGA overexpression is a constant feature of human malignancies, correlating with poor prognosis.
  • HMGA gene dysregulation via chromosomal rearrangements is common in benign mesenchymal tumors.

Purpose of the Study:

  • To review the involvement of HMGA proteins in cancer.
  • To analyze the mechanisms of HMGA's role in tumorigenesis.
  • To discuss HMGA-targeting cancer treatment potential.

Main Methods:

  • Literature review of existing studies on HMGA proteins in cancer.
  • Analysis of molecular mechanisms linking HMGA to tumorigenesis.
  • Exploration of therapeutic strategies targeting HMGA.

Main Results:

  • HMGA proteins are consistently overexpressed in human cancers, indicating their oncogenic role.
  • Chromosomal rearrangements involving HMGA genes are frequent in various neoplasms.
  • Emerging evidence suggests HMGA overexpression is critical in pituitary adenoma development.

Conclusions:

  • HMGA proteins play a crucial role in cancer development and progression.
  • Understanding HMGA's mechanisms provides insights into tumorigenesis.
  • Targeting HMGA represents a potential therapeutic strategy for various cancers.