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Related Concept Videos

Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Production of Formed Elements01:34

Production of Formed Elements

Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Bone Cells and Tissue01:30

Bone Cells and Tissue

Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...

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Hematopoietic cell types: prototype for a revised cell ontology.

Alexander D Diehl1, Alison Deckhut Augustine, Judith A Blake

  • 1The Jackson Laboratory, Bar Harbor, ME 04609, USA. adiehl@informatics.jax.org

Journal of Biomedical Informatics
|February 4, 2010
PubMed
Summary
This summary is machine-generated.

The Cell Ontology (CL) was revised to improve its representation of hematopoietic cells. These updates enhance the ontology's structure and content for better biomedical research applications.

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A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

Published on: October 25, 2018

Area of Science:

  • Biomedical Informatics
  • Cell Biology
  • Ontology Engineering

Background:

  • The Cell Ontology (CL) is a foundational resource for representing cell types across biology.
  • The CL requires significant updates to meet current biomedical ontology standards.
  • Existing CL structure and content present challenges for accurate biological representation.

Purpose of the Study:

  • To revise and improve the hematopoietic cell section of the Cell Ontology (CL).
  • To enhance the CL's structure, content, and adherence to OBO Foundry standards.
  • To establish a model for future improvements across the entire CL.

Main Methods:

  • Systematic revision of the hematopoietic cell type hierarchy within the CL.
  • Elimination of multiple inheritance in the asserted hierarchy.
  • Development of a framework for cross-product definitions using external ontologies.

Main Results:

  • Substantial improvements in the content and structure of the CL's hematopoietic cell section.
  • Removal of redundant and problematic multiple inheritance patterns.
  • Foundation laid for logical definitions integrating external biological knowledge.

Conclusions:

  • The revised hematopoietic cell section demonstrates a successful model for updating the Cell Ontology.
  • These improvements enhance the CL's utility for representing complex cell type relationships.
  • The applied methods provide a paradigm for the ongoing development and standardization of the CL.