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Executive function in early-treated phenylketonuria: profile and underlying mechanisms

Shawn E Christ1, Stephan C J Huijbregts, Leo M J de Sonneville

  • 1Department of Psychological Sciences, 210 McAlester Hall, University of Missouri, Columbia, MO 65203, USA. christse@missouri.edu

Molecular Genetics and Metabolism
|February 4, 2010
PubMed
Summary

Individuals with early-treated phenylketonuria (PKU) often show executive function (EF) deficits, particularly in working memory and response inhibition. Research is ongoing to clarify the pattern of impairment and its relationship to phenylalanine levels.

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