Related Experiment Video

Updated: Jun 16, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

[Treatment of metastatic kidney cancer in elderly subjects]

B Escudier1, P Paparel, Y Neuzillet

  • 1Unité d'Immunothérapie, Institut Gustave Roussy, Rue Camille Desmoulins, 94805 Villejuif, France. escudier@igr.fr

Progres En Urologie : Journal De L'Association Francaise D'Urologie Et De La Societe Francaise D'Urologie
|February 4, 2010
PubMed

Insights

Elderly patients with metastatic kidney cancer can receive the same treatments as younger patients. Current therapies show similar efficacy and satisfactory tolerance across all age groups, with no age-based dose adjustments needed.

Area of Science:

  • Oncology
  • Geriatric Medicine
  • Pharmacology

Context:

  • Metastatic kidney cancer treatment historically had age-related contraindications for certain therapies like interleukin-2 (IL2).
  • Advancements in targeted therapies have broadened treatment options for elderly cancer patients.
  • Phase III studies now routinely include patients aged 80 and older.

Purpose:

  • To evaluate the efficacy and safety of current metastatic kidney cancer treatments in elderly subjects.
  • To determine if age influences treatment outcomes or tolerance in renal cancer patients.
  • To provide evidence-based recommendations for age-specific dosing or treatment modifications.

Summary:

  • Treatment for elderly patients with metastatic kidney cancer is comparable to that for younger individuals.
  • New targeted therapies are effective and well-tolerated in patients of all ages, including those over 80.
  • While dose reductions may be slightly more frequent for certain drugs like sunitinib, no age-based dose adaptation is generally recommended.

Impact:

  • Supports the use of modern cancer therapies in elderly populations without age restrictions.
  • Suggests that age is not a limiting factor for efficacy or tolerance in most metastatic renal cancer treatments.
  • Informs clinical practice regarding the management of metastatic kidney cancer in older adults, emphasizing consistent treatment approaches.

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