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Updated: Jun 16, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

Relation between kidney function, proteinuria, and adverse outcomes.

Brenda R Hemmelgarn1, Braden J Manns, Anita Lloyd

  • 1Department of Medicine, University of Calgary, Calgary, Alberta, Canada. brenda.hemmelgarn@albertahealthservices.ca

JAMA
|February 4, 2010
PubMed
Summary
This summary is machine-generated.

Proteinuria significantly increases the risk of adverse outcomes like death and kidney failure, even with normal kidney function (eGFR). This highlights the need to incorporate proteinuria into chronic kidney disease risk assessments for better patient management.

Related Experiment Videos

Last Updated: Jun 16, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

Area of Science:

  • Nephrology
  • Cardiology
  • Public Health

Background:

  • Current chronic kidney disease (CKD) staging relies on estimated glomerular filtration rate (eGFR), but does not integrate proteinuria for risk stratification.
  • Proteinuria is independently associated with adverse clinical outcomes in CKD patients.

Purpose of the Study:

  • To investigate the combined association of reduced GFR and proteinuria with adverse clinical outcomes.
  • To determine if proteinuria modifies the risk associated with eGFR levels in a general adult population.

Main Methods:

  • A community-based cohort study of 920,985 adults in Alberta, Canada (2002-2007).
  • Utilized laboratory registry data for eGFR and proteinuria (urine dipstick or albumin-creatinine ratio [ACR]) measurements.
  • Assessed outcomes including all-cause mortality, myocardial infarction, and kidney failure progression.

Main Results:

  • Higher proteinuria levels were associated with increased rates of all-cause mortality, myocardial infarction, and kidney failure, independent of eGFR.
  • Individuals with heavy proteinuria and eGFR ≥ 60 mL/min/1.73 m² had more than double the mortality risk compared to those with moderate eGFR and no proteinuria.
  • Similar associations were observed for ACR and other adverse outcomes like end-stage renal disease.

Conclusions:

  • Proteinuria is an independent predictor of adverse outcomes in CKD.
  • The risk of mortality, myocardial infarction, and kidney failure is amplified by higher proteinuria levels at any given eGFR.
  • Clinical guidelines should consider incorporating proteinuria assessment for comprehensive CKD risk stratification.