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Updated: Jun 16, 2026

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Published on: December 30, 2016
Structure of bovine pancreatic ribonuclease complexed with uridine 5'-monophosphate at 1.60 A resolution
Steven B Larson1, John S Day, Chieugiang Nguyen
1Department of Molecular Biology and Biochemistry, The University of California, Irvine, CA 92697-3900, USA.
Abstract:
Bovine pancreatic ribonuclease A (RNase A) was crystallized from a mixture of small molecules containing basic fuchsin, tobramycin and uridine 5'-monophosphate (U5P). Solution of the crystal structure revealed that the enzyme was selectively bound to U5P, with the pyrimidine ring of U5P residing in the pyrimidine-binding site at Thr45. The structure was refined to an R factor of 0.197 and an R(free) of 0.253.

