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Brachial-ankle pulse wave velocity predicts silent cerebrovascular diseases in patients with end-stage renal diseases

Naoki Washida1, Shu Wakino, Koichi Hayashi

  • 1Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan. washida@sc.itc.keio.ac.jp

Journal of Atherosclerosis and Thrombosis
|February 4, 2010
PubMed

Insights

Arterial stiffness, measured by brachial-ankle pulse wave velocity (baPWV), is a significant predictor of cerebrovascular disease (CVD) severity in patients with end-stage renal disease (ESRD) before dialysis.

Area of Science:

  • Nephrology
  • Neurology
  • Cardiology

Background:

  • Cerebrovascular disease (CVD) significantly impacts prognosis in end-stage renal disease (ESRD) patients.
  • Understanding risk factors for CVD in ESRD is crucial for patient management.

Purpose of the Study:

  • To investigate the association between arterial stiffness and the development of CVD in pre-dialytic ESRD patients.
  • To identify novel determinants of CVD severity beyond traditional risk factors.

Main Methods:

  • Cerebrovascular disease (lacunes, carotid/intracranial artery stenosis) assessed via brain MRI and MRA in 44 pre-dialytic ESRD patients.
  • Severity of CVD evaluated by lacune count and degree of stenosis.
  • Association between CVD and atherosclerotic parameters, including arterial stiffness, was analyzed.

Main Results:

  • Severe lacunes correlated with older age, lower diastolic blood pressure, serum creatinine, and albumin, but higher CRP and serum calcium.
  • Brachial-ankle pulse wave velocity (baPWV) emerged as an independent risk factor for severe lacunes.
  • baPWV and intact parathyroid hormone (i-PTH) were independently associated with carotid/intracranial artery stenosis severity.

Conclusions:

  • Arterial stiffness, indicated by baPWV, may be a novel predictor of CVD severity in pre-dialytic ESRD patients.
  • These findings suggest that arterial stiffness assessment could aid in managing CVD risk in this population.
Abstract

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