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Related Experiment Videos

Pulmonary acinar development in diaphragmatic hernia.

Y Nakamura1, I Yamamoto, S Fukuda

  • 1Department of Pathology, St Mary's Hospital, Kurumeshi, Japan.

Archives of Pathology & Laboratory Medicine
|April 1, 1991
PubMed
Summary

Pulmonary hypoplasia in congenital diaphragmatic hernia shows varied acinar development. Factors like lung fluid retention and fetal movement influence lung growth, impacting outcomes.

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Area of Science:

  • Pediatric pathology
  • Developmental biology
  • Respiratory medicine

Background:

  • Congenital diaphragmatic hernia (CDH) often leads to pulmonary hypoplasia.
  • The development of lung acini in fetuses with CDH is not fully understood.
  • Assessing lung development is crucial for predicting patient outcomes.

Purpose of the Study:

  • To evaluate pulmonary acinar development in fetuses with diaphragmatic hernia.
  • To investigate the morphological and biochemical aspects of lung hypoplasia in CDH.
  • To identify factors influencing lung development in CDH cases.

Main Methods:

  • Autopsy examination of 17 cases with pulmonary hypoplasia and diaphragmatic hernia.
  • Light and electron microscopy for morphologic assessment.

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  • Radial alveolar count and surfactant phospholipid quantitation for morphometric study.

    • Main Results:

    • Pulmonary acinar development varied significantly among cases.
    • Most cases showed underdeveloped ipsilateral lungs compared to contralateral lungs.
    • Some cases exhibited well-developed lungs despite diaphragmatic hernia.

    Conclusions:

    • Acinar development in hypoplastic lungs associated with diaphragmatic hernia is inconsistent.
    • Oligohydramnios, polyhydramnios, and fetal respiratory movements are potential influencing factors.
    • Further research is needed to understand the complex factors affecting lung development in CDH.