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Related Concept Videos

B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:
Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR activation may...

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Related Experiment Video

Updated: Jun 16, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

New paradigms in basophil development, regulation and function.

Mark C Siracusa1, Jacqueline G Perrigoue, Michael R Comeau

  • 1Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA.

Immunology and Cell Biology
|February 4, 2010
PubMed
Summary
This summary is machine-generated.

Basophils play crucial roles in Th2 immunity and inflammation. This review explores their development, regulation, and function in immune responses to parasites and allergens.

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Last Updated: Jun 16, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
10:22

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Published on: September 16, 2011

Flow Cytometric Characterization of Murine B Cell Development
08:25

Flow Cytometric Characterization of Murine B Cell Development

Published on: January 22, 2021

Area of Science:

  • Immunology
  • Cell Biology
  • Inflammation Research

Background:

  • Basophils are key immune cells involved in Th2 cytokine-dependent responses.
  • Emerging evidence highlights their non-redundant functions in acute and chronic inflammation.

Purpose of the Study:

  • To review recent findings on basophil roles in immunity and inflammation.
  • To discuss pathways controlling basophil development, regulation, and effector functions.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of studies on basophil recruitment, antigen presentation, and Th2 cell differentiation.

Main Results:

  • Basophils are rapidly recruited to lymph nodes.
  • Basophils function as antigen-presenting cells.
  • Basophils are critical for Th2 cell differentiation and inflammatory responses to helminths and allergens.

Conclusions:

  • Basophils have essential roles in Th2-mediated immunity and inflammation.
  • Understanding basophil pathways offers insights into treating allergic and parasitic diseases.